A very interesting study in the journal Stem Cells looked at the affect of acupuncture to mobilize mesenchymal stem cells. In both humans and rats it showed increased mobilization of these cells when the acupuncture points Large Intestine 4 and 11 on the arm, and Du 14, on the spine, and 20, on the top of the head, were needled. It also showed increased functional connectivity between the hypothalamus, the master controller of hormones, and the amygdala, the emotional part of the brain. It also found reduced pain and increased tendon remodeling in the rats undergoing partial rupture of the Achilles tendon. This again shows central nervous system involvement in the affects of acupuncture, but adds the novel idea of stem cell involvement.